Scientists try to decode the genome of malaria mosquitoes


01/05 03:01

Russian researchers have worked to decode the genome of malaria mosquitoes, and scientists from the Institute of Genetics and Cytology of the Siberian Branch of the Russian Academy of Sciences believe that new methods of pest control can be developed using the decoded genome sequence.

According to the “RT” website, the institute’s scientists, in collaboration with their colleagues from the United States, decoded the genome of 5 species of malaria mosquitoes (Anopheles) and published the results of the study in the scientific journal Nature Communications. study may open new horizons for insect control, including Including genome editing methods.

It is noteworthy that the Anopheles mosquitoes that carry malaria die as a result of infection, killing more than 600,000 people each year. The efficacy of existing malaria vaccines is rather low.

The more common methods of vector control, such as draining swamps and treating areas with chemicals, damage the environment.

“The Hi-C method we used allowed us to decode the genome sequence of five species of Anopheles mosquitoes. This is very important information for those working on the development of vector control methods,” the Russian Institute’s press office said. .

Dr. said. Benjamin Fishman, principal investigator at the Institute of Genetics: “It is possible to develop new methods of insect control and genome editing using mutagenic chain reaction (a process by which an artificial system can reproduce and make changes in the genome). affects a specific mosquito gene, It is essential to understand the components of its genome.

Through the study, the scientists were able to see the structure of the genome of the Anopheles mosquito. Scientists expected that a fold of DNA would contain many loops. But otherwise a long molecule can not be packed into a small nucleus. Another interesting thing is that these loops, it seems, are located in non-random, not static, but dynamic places.

It appears that the location of the loops directly affects how the DNA “works,” Fishman said.As far as the penetration of the structure of the molecule is concerned, the reason lies in the presence of a number of genetic diseases.

The press office noted that by building a 3-D map of the mosquito’s genome, scientists could see unusual features of its structure.

“The cells of malaria mosquitoes experience the formation of large rings, and at their base meet the distant parts of the genome, and such an encounter cannot be held by chance,” Fishman said. By chance every morning. We may have found a new loop-forming mechanism in DNA, because none of the previously known loops work. “

“We plan to make more observations to understand what this mechanism does to mosquitoes, and whether it is unique to insects, or also occurs in other organisms.”

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Russian researchers have worked to decode the genome of malaria mosquitoes, and scientists from the Institute of Genetics and Cytology of the Siberian Branch of the Russian Academy of Sciences believe that new methods of controlling insects can be developed using sequencing. .

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