Researchers identify genetic variations associated with severe cases of corona

A number of researchers have identified genetic variations that make people susceptible to the development of severe forms of Covid.

In a study involving more than 57,000 people, researchers discovered 16 new DNA changes. [الحمض النووي الريبوزي منقوص الأوكسجين] Associated with severe cases of “Covid-19”.

The aforementioned discoveries were made by researchers members of the GenOMICC consortium, knowing that it is a form of worldwide collaboration involved in the study of genetic traits in serious diseases, and under the supervision of the Scottish University of Edinburgh in partnership with Genomics England is. , by determining the order of The genomes of 7 491 patients from 224 intensive care units in the United Kingdom.

The researchers compared the DNA of these patients with that of 48,400 other people who were not infected with the “Corona” virus, as well as the DNA of 1,630 other people who encountered mild forms of “Covid”.

The mutation that the researchers identified in the 16 genes naturally occurs in the body’s immune, inflammatory and clotting pathways. But these differences have an impact on the severity of Covid disease.

The findings, published in the scientific journal Nature, reveal how a single genetic mutation was sufficient to increase a patient’s risk of serious illness, suggesting that treatments and drugs could be designed or adapted to treat Covid in its early stages. help control.

“Our recent results suggest forms of [عينة] Specific molecular profiles in critically ill COVID-19 patients, ”said Professor Kenneth Bailey, lead researcher on the project and a consultant in critical care medicine at the University of Edinburgh.

According to Professor Bailey, these findings explain why some people develop life-threatening forms of Covid-19, while others do not experience symptoms at all.

“But more importantly,” adds Professor Bailey, the study results “provide us with an in-depth understanding of the course of the disease and represent a major step forward in finding more effective treatments.” [لـكوفيد-19].

Also in this regard was Professor Mark Caulfield from Queen Mary University of London, who was previously a senior scientist at Genomics England and a co-researcher on the study, and said that “given that (Covid-19) is working to develop, we must Our focus is to reduce the number of patients who develop critical illnesses that require hospitalization. ”

“Through our complete genome-sequence research, we have discovered emerging genetic mutations that make people susceptible to serious diseases, paving the way for new tests and treatments, to help protect people and (National Health Service) in Britain from this virus,” the professor, Caulfield.

According to the researchers, not all changes in specific DNA will take place [التي حددناها ورصدنا] Everyone has it, so some people will be at greater or lesser risk for serious health consequences [جراء “كوفيد-19”].

“I think we can say today that these mutations do indicate people who are at greatest risk of developing serious diseases.” [من “كوفيد-19”]As explained by Professor Mark.

“And if we know of the presence of these mutations in patients early in the course of their disease, then we can consider early therapeutic intervention by using some of the drugs we talked about, such as dexamethasone. [ينتمي إلى عائلة “كورتيكوستيرويد” (= “ستيرويد”)] or others in an effort to prevent serious health consequences. ”

But it is true that doctors, brand experts, can possibly make predictions about patients based on their own genome, the technology is not yet available.

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“I think most doctors will tell you that the first time we saw our patients with this disease was quite upsetting and confusing, as we have never seen anything like it,” Professor Bailey said.

“There was a great feeling that we did not understand this form of the disease, and we stood helpless and did not know what to do,” Professor Bailey added.

Now, according to Professor Bailey, we have “three effective therapies against the suppression of the immune response in humans, and 23 strong genetic links to determine disease mechanisms, which means we have come an extraordinary way of progress.” [في التشخيص والعلاج]”.

Commenting on the study, Andrew Mumford, a professor of hematology at the University of Bristol, said: “To understand the genetic basis of the response method. [تفاعل الجسم] With COVID-19, it can improve expectations about whether some patients will develop a severe form of the disease individually. “

Some of the genes identified in the study were previously identified and are targets for currently approved treatments for “Covid-19”. Other genes represent new targets for drugs that are considered promising and will be included in future clinical studies.

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