The College of Science and Engineering at Hamad Bin Khalifa University is developing a drug treatment…

(MENAFN- Hamad Bin Khalifa University) DOHA, 17 August 2022- The College of Science and Engineering at Hamad Bin Khalifa University has contributed to an international study that has achieved important results that could help face the challenge of increasing drug resistance in tuberculosis to offer when it is used to treat this infectious disease, which is currently the leading cause of death due to infectious diseases worldwide.

Dr. Tanweer Alam, Assistant Professor in the Department of Information Technology and Computing at the college, and collaborators from the infectious disease research centers in South Africa, Cameroon, the United Kingdom, New Zealand and Japan, published the results of their influential research. in the field of DNA therapy, in scientific journals ranked among the best specialized journals in the field Discover drugs in the Scopus database.

Tuberculosis cases are mainly caused by the bacteria Mycobacterium tuberculosis, and the disease kills more than 1.6 million people worldwide each year. With multidrug-resistant strains of tuberculosis (MDR-TB) considered a global threat to large-scale TB control efforts, there is an urgent need for innovations targeting host-pathogen interactions as a strategy to combat this problem. to address.

In this study, the authors evaluated the role of a specific long noncoding RNA during infection with the HN878 strain of Mycobacterium tuberculosis. RNA, found in all living cells, is a genetic molecule that has structural similarities to DNA. Although some long non-coding RNAs play an important role in the functioning of immune cells, the assessment of their role in bacterial infections has not yet been adequately studied. In this study, the world-class high-performance computing facilities at the College of Science and Engineering and the Bioinformatics Laboratory where Dr. Tanweer Alam work, enabled the team to perform the large-scale genomic and transcriptomic analysis required in such studies.

The results of the study concluded that the long non-coding RNA (MIR99AHG) is a positive control of inflammation and intracellular growth, making it a potential target as an adjunct (adjunctive therapy) to existing antibiotics that used in the treatment of tuberculosis, if it has been developed as a host-targeted drug therapy. the disease.

Host-targeted drug therapies are critical to achieving the WHO’s “Strategy to End Tuberculosis” by 2035. These therapies offer hope for the individualized treatment of tuberculosis infection, given their potential to shorten the course of treatment, prevent antibiotic resistance, and reduce the risk of lung damage by enhancing autophagy, antimicrobials, and other macrophage effector mechanisms. These drug therapies may help advance precision medicine approaches to drug treatment of tuberculosis.

Dr. Tanweer Alam, a leading expert in long non-coding RNA studies, said: “We have studied the role of long non-coding RNA in tuberculosis well. However, there is limited data available on the role of long non-coding RNA in disease incidence. The role of this particular acid is through the analysis of large amounts of genomic and transcriptomic data Given that tuberculosis remains the leading cause of death from infectious diseases worldwide, in addition to the challenges posed by drug-resistant strains and co-morbidities, research collaborations Innovation of critical importance.Having the College of Science and Engineering possess key computing capabilities that can help unlock the full potential of genomic research and provide it to researchers around the world enables the College to play a role in addressing global challenges.”

On this occasion, Dr. Mounir Hamdi, founding dean of the College of Science and Engineering, said: “The Faculty of the College of Science and Engineering is widely regarded, as they are known for their tireless pursuit of high-impact research. Dr. Tanweer’s contributions to this study once again demonstrate that our expertise Our capabilities help to achieve important societal goals, and in this case, the development of PM approaches to overcome the burden of diseases present in the country is of particular importance.”

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